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Advancing Brillouin Imaging and Correlative Spectroscopy
Bio- and Advanced Materials
LAB-ICS
Laboratory of Advanced Bio-Imaging and Correlative Spectroscopy
LAB-ICS
Department of Physics and Geology, University of Perugia
Via Alessandro Pascoli, 06123 Perugia (Italy)
Email: info@lab-ics.com
Copyright @ 2025 LAB-ICS. All Right Reserved.
News
New paper published in Advanced Science!
We are pleased to announce the publication of our latest work introducing Brillouin–Raman Microspectroscopy on-a-Chip, an integrated, label-free setup to probe mechano-chemical dynamics in 3D biological systems under controlled mechanical deformation, by combining Brillouin and Raman microscopy within microfluidic devices.
Applied to breast tumor spheroids, the platform reveals how rapid, cyclical mechanical deformations—mimicking in vivo stresses—drive profound changes in tumor physiology, including nuclear shape remodeling, transcriptional reprogramming with a strong upregulation of ATF3 and global spheroid stiffening.
This work was carried out as an interdisciplinary project coordinated by LAB-ICS and Dr. Brenda Green and Prof. Giorgio Scita @ IFOM -Milan.
Our lab featured on ANSA Science!
We are glad to see the results of an international collaboration we contributed to highlighted by a national science news outlet!
Upcoming Event!
We are delighted to host the Summer School “BioBrillouin for Mechanobiology: Materials, Methods and Perspectives”, taking place from July 6th to 9th in the beautiful city of Perugia!
This school is organized as satellite meeting of the EBSA 2025 conference in Rome.
We look forward to welcoming you!
6-9 July, 2025, Perugia, Italy
30 June - 4 July 202515th European Biophysics Congress
